From Baltimore, MD (4 ½ hours):
Follow I-70 West to I-68 West (Hancock, MD) to I-79 South (Morgantown, WV). Follow I-79 South to Exit 99 (Weston-Buckhannon exit).

From Charleston, WV (1 ¾ hours)
Follow I-79 North to Exit 99 (Weston-Buckhannon exit).

From Charlotte, NC (6 hours)
Follow I-77 North to US Rt. 19 (North Beckley, WV) to I-79 North to Exit 99 (Buckhannon-Weston exit).

From Columbus, OH (4 hours)
Follow I-70 West to I-77 South (Cambridge, OH) to US Rt 50 East (Parkersburg, WV) to I-79 South (Clarksburg, WV) to Exit 99 (Weston-Buckhannon exit)

From Harrisburg, PA (4 ½ hours)
Follow I-81 South to I-70 West (Hagerstown, MD) to I-68 West (Hancock, MD) to I-79 South (Morgantown, WV). Follow I-79 South to Exit 99 (Weston-Buckhannon exit)

From Pittsburgh, PA (2 ¼ hours)
Follow I-79 south to Exit 99 (Weston-Buckhannon exit)

From Roanoke, VA (4 ¼ hours)
Follow I-81 North to US Rt. 220 North to I-64 West to I-77 North (Beckley, WV) to US Rt. 19 North (North Beckley, WV) to I-79 North to Exit 99 (Buckhannon-Weston exit)

From Washington DC (4 ½ hours)
Follow I-270 North to Frederick, MD. Follow I-70 west to I-68 West (Hancock, MD) to I-79 South (Morgantown, WV). Follow I-79 South to Exit 99 (Weston-Buckhannon exit)